Pulse Oximetry and BluPRO
Operating Room
Recovery Room
- Oxygenation assessment after anesthesia in the perioperative period
ICU
- Respiratory management under ventilation
- Weaning index
- Respiratory management of patients with sedatives or analgesics
NICU
- Detection of hypoxemia
- Oxygen management to prevent retinopathy of prematurity
Wards
- Vital sign monitoring by SpO2 and pulse rate
- Spot check monitoring of oxygen levels during rounds
Emergency Room
- Management of oxygen administration
Laboratory
- Detecting hypoxemia during tracheal stroscopy or endoscopy
SpO2 is the arterial blood oxygen saturation measured transcutaneously with a pulse oximeter, which quantifies the percentage of hemoglobin that is bound to oxygen of the red blood cells in arterial blood. Hemoglobin turns bright red when bound to oxygen, and it turns dark red when unbound. The oxygen saturation of arterial blood is calculated by utilizing the fact that the ease of absorbing light differs depending on the color. Two types of light of the small devices attached to the fingertips of the hand, and the sensor on the other side measures the light that passes through the finger without being absorbed and analyzes it.
- A probe with two LEDs (660 mm for red light and 940 mm for infrared light at Nihon Kohden) is attached to a part of the body with relatively thin tissue, such as a finger or toe.
- A photo detector detects the two wavelengths that pass through the measurement site and calculates the oxygen saturation of arterial blood from the pulse wave, absorbance and amount of blood obtained from the 2 signals.
Reference
1) [Improvement of Earpiece, oximeter] (in Japanese). Japanese Society for Medical and Biological Engineering Abstract. 12, 90-91, 1974.
2) [The Birth of the Pulse Oximeter and its Theory] (in Japanese). The Journal of Japan Society for Clinical Anesthesia. 10(1), 1-11, 1990.
3) [Pulse Oximetry and Its Simulation] IEEE Tokyo Section Denshi Tokyo. 29, 184-186, 1990.
4) Takuo, Aoyagi. [Theoretical and Experimental Investigations of Blood Dimming] (in Japanese). Japanese journal of medical electronics and biological engineering : JJME. 30(1), 1-7, 1992.
SpO2 is calculated the amplitude ratio Φ of the pulse waves of two wavelengths of red and infrared light emitted by LEDs. Nihon Kohden’s pulse oximeter plots the pulse wave signals of infrared light and red light on the XY coordinate axes as shown in Figure 1 and calculates Φ from the slope of the regression line obtained by the least square method. Since this method uses all of the waveform data, it enables more accurate calculation of Φ than the method that uses only the maximal and minimal amplitude.
The NPi algorithm enhance the filtering function that removes artifacts from the pulse wave while maintaining the basic processing of the conventional algorithm. Its characteristic features are the extraction of the fundamental frequency of pulse wave by frequency analysis (Figure 2) and the removal of artifacts using a narrow-band filtering based on that frequency analysis. This function is especially effective when there are relatively large artifacts in the pulse wave amplitude, such as when a patient with peripheral circulatory failure becomes restless, or in the case of respiratory variation with neonates.
Pulse waves have a fundamental frequency that is the same as the pulse rate the pulse rate and a frequency component that is a constant multiple of this frequency (Figure 3). When performing frequency analysis of a waveform with a large superimposed artifact, it is difficult to identify the pulse wave frequency because the pulse wave signal gets lost in the artifact (Figure 3b). Even in such situations, using Nihon Kohden’s original coordinate-transform method improves the discrimination between pulse wave and artifacts.
Frequency analysis of the pulse wave signal obtained by separating it from the artifact with this coordinate-transform method allows the frequency of the pulse wave to be identified (Figure 3c).
Based on the pulse wave signal obtained by separating it from artifacts with the coordinate-transform method as shown in Figure 4, a narrow-band filter (patented) is used to filter out signals affected by artifacts to accurately extract signals and calculate the pulse wave signals Φ.
This method has long been known in the world of signal processing technology, but its application to pulse oximeters has made it possible to accurately separate artifacts from signals and provide highly reliable SpO2 values.
